A Brønsted Acidic Deep Eutectic Solvent for N-Boc Deprotection

The tert-butyloxycarbonyl (Boc) group is one of the most widely used amine-protecting groups in multistep reactions synthetic organic chemistry as well peptide synthesis. Traditional methods to remove Boc have disadvantages terms high acidity, use expensive reagents, excessive amounts catalysts and harmful solvents temperatures, making them environmentally unsustainable. Therefore, more efforts must be stepwise tightened make removal practical, clean, minimize any potential impact. We describe an efficient sustainable method for N-Boc deprotection by means a choline chloride/p-toluenesulfonic acid deep eutectic solvent (DES), which reaction medium plus catalyst. adopted conditions allow wide variety derivatives excellent yields. strategy has found advantages greening, simplicity, short times, resulting useful alternative standard methods.